Over-expressing Akt in T cells to resist tumor immunosuppression and increase anti-tumor activity

Microenvironment Immunity within the Ovarian Tumor Eliminate Immunosuppression and Activate Chimeric NKG2D Expressing T Cells

Immunity within the Ovarian Tumor Eliminate Immunosuppression and Activate Chimeric NKG2D Expressing T Cells

Tumor sialylation impedes T cell mediated anti-tumor responses while promoting tumor associated-regulatory T cells

The increased presence of sialylated glycans on the tumor surface has been linked to poor prognosis, yet the effects on tumor-specific T cell immunity are hardly studied. We here show that hypersialylation of B16 melanoma substantially influences tumor growth by preventing the formation of effector T cells and facilitating the presence of high regulatory T cell (Treg) frequencies. Knock-down of...

Mitochondrial activity regulates T cell memory, self renewal and anti tumor function in CD8+ T cells

The ability of tumor-reactive CD8+ T cells to eradicate tumors following adoptive transfer of autologous tumorinfiltrating lymphocytes correlates with their capacity to proliferate and persist for long periods of time. These qualities are found predominantly in naive and less differentiated memory cells including memory stem cells (TSCM) and central memory cells (TCM), but the metabolic control...

Apatinib has anti-tumor effects and induces autophagy in colon cancer cells

Objective(s): Apatinib recently has been used to treat patients with gastric cancer, but the function of apatinib in colon cancer remains unclear. This study was conducted to investigate the impacts of apatinib on the biological function and its potential mechanism of colon cancer cells in vitro. Materials and Methods:The effect of apatinib in colon cancer cells were detected by assessing cell ...